This Arduino-based quartz crystal microbalance is capable of measuring forces down to 700 picograms. A wonderful design as well.

The clever folks over at [Novaetech SRL] have unveiled openQCM, their open-source quartz crystal microbalance. A QCM measures very minute amounts of mass or mass variation using the piezoelectric properties of quartz crystal. When an object is placed on the surface of this sensor, the changes in the crystal’s resonant frequency can be detected and used to determine its mass in a variety of experimental conditions (air, vacuum, liquid). However, most QCM technology is proprietary and pricey – at least US$3000 for the microbalance itself. Any consumables, such as additional crystals, cost several hundred dollars more.

Source: Measure as Little as You Want with openQCM | Hackaday